New in Solu: AMR point mutations, Genome size check

Do not index

We've been building new features that you've been asking for and we're excited to run through everything we added this month.

AMR point mutations

AMR point mutations are retrieved from the NCBI Gene catalog and available for the 25 most common organisms. This includes results like gyrA mutations that have relevance for antimicrobial resistance.

Example result with point mutations included

In the same vein, some intrinsic resistance genes are no longer reported - this should increase the relevance of the AMR report.

Virulence, biocide resistance, and stress genes

Virulence, biocide resistance and generic AMR genes are now reported in the app as well. Look for “Additional hits” right under the AMR table.

Example of additional hits: mexA, mexE and mexX for Pseudomonas aeruginosa — Example of additional hits: mexA, mexE and mexX for *Pseudomonas aeruginosa*

Genome size check and additional QA steps

Quickly estimate completeness with genome size checking

Solu Platform now compares your genome size to NCBI’s upper and lower limits. You can more easily check how well the genome size matches the expected range.

Similarly, the platform now warns if the genome is less than 1Mbp in size or if it has over 200 contigs – both likely to read to decline in downstream analysis quality.

Simplified sample page

The sample page has been simplified, and you’ll now see AMR and SNP distances directly from the sample’s main pane without needing to navigate to an analysis tab.

Some of the previously updated AMR highlights – mcr, ESBL and carbapenemase genes, and methicillin resistance gene families are also highlighted on the sample page.

Other updates and improvements

Improved functionality on smaller screens – the tables will now fit better on a typical 13” laptop screen

Updates to the visual look and feel

Improved robustness towards variable input files - we now run additional validation, harmonization and QC steps for input files.